Major Cost Drivers in Assessing the Economic Burden of Alzheimer’s Disease: A Structured, Rapid Review

Background: Alzheimer’s Disease is the most common cause of dementia, affecting memory, thinking and behavior. Symptoms eventually grow severe enough to interfere with daily tasks. AD predicted increase healthcare spending costs associated formal informal caregiving. The aim this study was identify quantify contribution different cost components AD. Methods: A structured literature review conducted studies reporting economic burden Alzheimer`s beyond setting. search in Medline, Embase EconLit limited published last 10 years. For each identified component, frequency weighted mean were calculated across countries estimate percentage component by care setting disease severity. Results obtained costing approach also compared. Results: community-dwelling adults, healthcare, social indirect total 13.9%, 17.4% 68.7%, respectively. varied severity 26.0% 10.4% spent on for mild disease, proportion changed from 60.7% 72.5% as progressed. those residential care, similar between moderate disease. Social accounted average 85.9% costs. Conclusion: overall not negligible; but generally exceeded